Substrate-specific pharmacokinetic interaction between endothelin receptor antagonists and phosphodiesterase-5 inhibitors - assembling the clues
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Spinally mediated analgesic interaction between γ-aminobutyric acid B receptor agonist and glutamate receptor antagonists in rats
Background. Many mechanisms are involved in pain transmission in the spinal cord. Therefore, combination of drugs acting on different kinds of mechanisms might be useful for analgesia. We investigated the interaction betweenγ-aminobutyric acid （GABA）B receptor agonist, baclofen, and N-methyl-D-aspartate （NMDA） receptor antagonist, AP-5, orα-amino-3-hydroxy-5-methylisoxazole-4-propionic acid ...
متن کاملEvolution of Phosphodiesterase-5 Inhibitors.
Correspondence to: Du Geon Moon Department of Urology, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea. Tel: +82-2-2626-3201, Fax: +82-2-2626-1321, E-mail: [email protected] Copyright © 2015 Korean Society for Sexual Medicine and Andrology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://c...
متن کاملPulmonary responses to selective phosphodiesterase-5 and phosphodiesterase-3 inhibitors.
OBJECTIVE To compare the direct pulmonary vasodilating activity and specificity of phosphodiesterase-5 (zaprinast) and phosphodiesterase-3 (milrinone) inhibitors on the pulmonary vascular (PV) bed of the spontaneously breathing cat with an intact chest. DESIGN Prospective, randomized animal study. SETTING Laboratory of university hospital. SUBJECTS Experiments were performed in vivo in in...
متن کامل[5-phosphodiesterase inhibitors and cardiovascular risk].
important predictors of erectile dysfunction. Am J Epidemiol 1994;140:930—7. [7] Roumeguère Th, Wespes E, Carpentier Y, Hoffmann P, Schulman CC. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur Urol 2003;44:355—9. [8] Ponholzer A, Temml C, Obermayr R, Wehrberger C, Madersbacher S. Is erectile dysfunction an indicator for increased ...
متن کاملCombination therapy with beta-adrenergic receptor antagonists and phosphodiesterase inhibitors for chronic heart failure.
Abstract Rational use of phosphodiesterase inhibitors represents an ongoing controversy in contemporary pharmacotherapy for heart failure. In randomized clinical trials, phosphodiesterase inhibitors increased cardiac output at the expense of worsening the rates of sudden cardiac death and cardiovascular mortality. Preliminary findings from ongoing clinical and preclinical investigations of phos...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2009
ISSN: 0306-5251,1365-2125
DOI: 10.1111/j.1365-2125.2009.03374.x